This lookt like a Vincent Van Gogh painting to me, so I did some research. It's one of several versions of Van Gogh's "La Berceuse," painted between late 1888 and early 1889.
Here's a version from the Museum of Fine Arts, Boston:
Here's a version from the Met (with the notable difference of the hands' being folded the opposite direction):
I lookt at some other versions, but I couldn't positively identify which version was used in "The Picture Frame." Whichever version was used, I'm sure it was a reproduction and not the original painting.